Literature summary extracted from

An, J.; Woodward, J.J.; Sasaki, T.; Minie, M.; Elkon, K.B.
Cutting edge: Antimalarial drugs inhibit IFN-beta production through blockade of cyclic GMP-AMP synthase-DNA interaction (2015), J. Immunol., 194, 4089-4093.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.7.86	9-amino-6-chloro-2-methoxyacridine	antimalarial drug, inhibits dsDNA stimulation of cGAS. IC50 value for interferon IFN-beta 0.0053 mM	Homo sapiens
2.7.7.86	Quinacrine	antimalarial drug, inhibits dsDNA stimulation of cGAS. IC50 value for interferon IFN-beta 0.0037 mM	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.7.86	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.7.86	HEK-293T cell	-	Homo sapiens	-
2.7.7.86	THP-1 cell	-	Homo sapiens	-

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
2.7.7.86	0.013	-	pH 7.5, 22°C	Homo sapiens	Quinacrine
2.7.7.86	0.032	-	pH 7.5, 22°C	Homo sapiens	9-amino-6-chloro-2-methoxyacridine

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Release 2023.1 (January 2023)